People : Primary Faculty

Shari Messinger Cayetano, M.E., Ph.D.

Contact Information

Associate Professor, Department of Public Health Sciences, Division of Biostatistics
Director of Biostatistics Collaboration and Consulting Core

PO Box 016069
Miami, FL 33101

Clinical Research Bldg, R-669
1120 NW 14th Street, Room 1062
Miami, FL 33136
Phone: 305-243-4465
Fax: 305-243-4612

smessinger@biostat.med.miami.edu
Collexis Profile

Research Interests

Statistical methods useful for application in the areas of drug abuse, AIDS and diabetes

Recent Publications

Perayra, M., Metsch, L., Tomar, S., Valverde, E., Jeanty, Y., Messinger, S., Boza, H. Utilization of dental care services among low income HIV-positive persons in primary care. To appear in AIDS Care.

Yamamoto, T., Mita, A., Ricordi, C., Messinger, S., Miki, A., Sakuma, Y., Barker, S., Fornoni, A., Molano, R.D., Inverardi, L., Pileggi, A., Ichii, H. Prolactin Supplementation to Culture Medium Improves Beta-Cell Survival. Transplantation, 89: 1328-35, 2010

Mita, A., Ricordi, C., Messinger, S., Miki, A., Misawa, R., Barker, S., Molano, R.D., Haertter, R., Alvarez, A., Khan, A., Pileggi, A., Miyagawa, S., Inverardi, L., Ichii, H. Anti-proinflammatory Effects of Purification Method Using Iodixanol (OptiPrep)-Based Density Gradient on Human Islet Preparations. To appear in Cell Transplantation, 2010

Metsch, L.R., Pereyra, M., Messinger, S., del Rio, C., Strathdee, S.A., Anderson-Mahoney, P., Rudy, E., Marks, G., Gardner, L., for the ARTAS Study Group. HIV Transmission Risk Behaviors among HIV Infected Persons who are Successfully Linked to Care. Republished in 2009 Clinical Issues in HIV Medicine: Recent Advances & Challenges, 166-173, 2009

Faradji, R. N., Froud, T., Messinger, S., Monroy, K., Pileggi, A., Mineo, D., Thipaporn, T., Mendez, A., Ricordi, C., Alejandro, R.; Long-Term Metabolic and Hormonal Effects of Exenatide in Islet Transplant Recipients with Allograft Dysfunction. Cell Transplantation, 18; 1247-59, 2009.
Tharavanij, T., Froud, T., Leitao, C., Baidal, D., Paz-Pabon, C., Messinger, S., Cure, P., Bernetti, K., Ricordi, C., Alejandro, R. Clinical Use of Fructosamine in Islet Transplantation Thipaporn Tharavanij. Cell Transplantation, 18; 453-458, 2009.

Leitao, C., Cure, P., Messinger, S., Pileggi, A., Lenz, O., Froud, T., Faradji, R., Selvaggi, G., Kupin, W., Ricordi, C., Alejandro, R.; Stable Renal Function After Islet Transplantation: Importance of Patient Selection and Aggressive Clinical Management. Transplantation, 87: 681-688, 2009.

Baidal, D., Faradji, R., Messinger, S., Froud, T., Monroy, K., Ricordi, C., Alejandro, R.; Early Metabolic Markers of Islet Allograft Dysfunction. Transplantation, 87: 689-697, 2009.

Miki, A., Ricordi, C., Messinger S., Yamamoto, T., Mita A., Barker, S., Haetter, R., Khan, A., Alejandro, R., Ichii, H.; Toward Improving Human Islet Isolation from Younger Donors; Rescue Purification is More Efficient for Trapped Islets. Cell Transplantation 18; 13-22, 2009.

Metch, L., Pereyra, M., Messinger, S., del Rio, C., Strathdee, S. A., Anderson-Mahoney, P., Rudy, E., Marks, G., Gardner, L.; Continuing Risk Behaviors among HIV-positives not in HIV care: A Longitudinal Examination. Clinical Infectious Diseases 47; 577-584, 2008.

Estrada E, Valacchi F, Nicora E, Brieva s, Esteve C, Echevarria L, Froud T, Bernetti K, (Cayetano) Messinger S, Velazquez O, Alejandro R, Ricordi C. Combined Treatment of Intrapancreatic Autologous Bone Marrow Stem Cells and Hyperbaric Oxygen in Type 2 Diabetes Mellitus. Cell Transplantation, 17; 1295-1304, 2008.

Faradji RN, Tharavanij T, Messinger S, Froud T, Pileggi A, Monroy K, Mineo D, Baidal DA, Cure P, Ponte G, Mendez A, Selvaggi G, Ricordi C, Alejandro R. Long Term Insulin Independence and Improvement of Glucose-Induce Insulin Secretion After Supplemental Islet Infusion Exenatide Treatment. Transplantation, 86:1658-65, 2008

Tharavanij, T., Betancourt, A., Messinger, S., Cure, P., Baidal, D., Leitao, C., Bernetti, K., Froud, T., Ricordi, C., Alejandro, R.; Improved Long-term Quality of Life after Islet Transplantation. Transplantation 86; 1161-1167, 2008.

Froud, T., Faradji, R., Pileggi, A., Messinger, S., Baidal, D., Ponte, G., Cure, P., Monroy, K., Mendez, A., Selvaggi, G., Ricordi, C., Alejandro, R.; The Use of Exenatide in Clinical Islet Transplant Recipients Demonstrating Chronic Islet Allograft Dysfunction. Transplantation 86(1): 36-45, 2008.

Gorn, L., Faradji, R., Messinger, S., Monroy, K., Baidal, D., Froud, T., Mastrototaro, J., Ricordi, C., Rodolfo A.; Impact of Islet Transplantation on Glycemic Control as Evidenced by CGMS. Journal of Diabetes Science and Technology (2): 221-8, 2008.

Cure, P., Pileggi, A., Froud, T., Messinger, S., Faradji, R., Baidal, D., Cardani, R., Pugliese, A., Betancourt, A., Esquenazi, V., Ciancio, G., Burke, G., Selvaggi, G., Ricordi, C., Alejandro, R.; Improved Metabolic Control and Quality of Life in Seven Patients with Type 1 Diabetes Following Islet After Kidney Transplantation. Transplantation 85(6): 801-12, 2008.

Poggioli, R., Faradji, R., Messinger, S., Enfield, G., Cure, P., Ponte, G., Baidal, D., Froud, T., Ricordi, C., Alejandro, R.; Assessment of Modifications in Nutritional Status and Behavior in Subjects with Type 1 Diabetes, Before and After-Islet Transplantation. Transplantation 85(4): 501-6, 2008.

Yamamoto, T., Ricordi, C., Messinger, S., Sakuma, Y., Miki, A., Rodriguez, R., Haertter, R., Khan, A., Alejandro, R., Ichii, H.; Deterioration and Variability of Highly Purified Collagenase Blends Used in Clinical Islet Isolation.. Transplantation 84(8): 997-1002, 2007.

Ponte, G., Pileggi, A., Messinger, S., Alejandro, A., Ichii, H., Baidal, D. A., Khan, A., Ricordi, C., Goss, J. A., Alejandro, R.; Toward Maximizing the Success Rate of Human Islet Isolation: Influence of Donor and Isolation Factors. Cell Transplantation 16: 595-607, 2007.

Faradji, R., Monroy, K., Messinger, S., Pileggi, A., Froud, T., Baidal, D., Cure, L., Ricordi, C., Luzi, L., Alejandro, R.; Simple Measures to Assess and Monitor β–cell Mass and Function After Islet Transplantation. American Journal of Transplantation 7(2): 303-8, 2007.

Faradji, R., Monroy, K., Riefkohl, A., Lozano, L., Gorn, L., Froud, T., Cure, P., Baidal, D., Ponte, G., Messinger, S., Mastrototaro, J., Ricordi, C., Alejandro, R.; Continuous Glucose Monitoring System For Early Detection of Graft Dysfunction in Allogenic Islet Transplant Recipients. Transplantation Proceedings 38: 3274-6, 2006.

Hirohito I., Wang, X., Messinger, S, Alvarez A., Fraker, C., Khan, A., Kuroda, Y., Inverardi, L., Goss, J., Alejandro, R., Ricordi, C.; Improved Human Islet Isolation Using Nicotinamide. American Journal of Transplantation 6: 2060-8, 2006.

Poggioli, R., Ponte, G., Baidal, D., Cure, P., Pileggi, A., Messinger, S., Betancourt, A., Froud, T., Faradji, R., Ricordi, C., Alejandro, R.; Quality of Life after Islet Transplantation. American Journal of Transplantation 6: 371-8, 2006.

Messinger, S. and Murray, S.; Nonparametric Two-Sample Tests for Paired Censored Survival Data with Longitudinal Covariates. Statistics in Medicine 24: 301-18, 2005.

Ichii, H., Inveradi, L., Pileggi, A., Molano, R. D., Messinger, S.; A Novel Method for the Assessment of Cellular Composition and Beta-Cell Viability in Human Islet Preparations. American Journal of Transplantation 5:1635-45, 2005.

Messinger, S. and Murray, S.; Nonparametric Paired Two-Sample Tests for Censored Survival Data Incorporating Baseline Covariate Information. Far East Journal of Theoretical Statistics 16: 137-75, 2005.

Hafiz, M., Faradji, R.N., Froud, T., Pileggi, A., Baidal, D., Cornejo, A., Cure, P., Ponte, G., Poggioli, R., Messinger, S., Ricordi, C., Alejandro, R.; Immunosuppression and Procedure Related Complications in 26 Patients With Type 1 Diabetes Mellitus Receiving Islet Cell Transplantation. Transplantation 90: 1718-28, 2005.

Zhou, H., Marriott, D., Messinger, S., Brown, M., Brandle, M., and Herman, W.; A Computer Simulation Model of Diabetes Progression, Quality of Life, and Cost. Diabetes Care 28: 2856-2863, 2005.

Faradji, R.N., Monroy, K., Cure, P., Froud ,T., Baidal, D., Pileggi, A., Messinger, S., Ricordi, C., Alejandro, R.; C-peptide Values in the Peritransplant Period after Intraportal Islet Infusions in Type 1 Diabetes. Transplantation Proceedings 37: 3433-34, 2005.

Hafiz, M., Poggioli, R., Caulfield, A., Messinger, S., Geiger, M. C., Baidal, D., Froud, T., Ferriera, J., Tzakis, A., Ricordi, C., Alejandro, R.; Cytomegalovirus (Cmv) Serological Status In Patients With Type 1 Diabetes Mellitus Awaiting Islet Allograft Transplantation. American Journal of Transplantation 4: 1697-1702, 2004.

Other Works, Publications, Abstracts

Linetsky, E, Rodriguez, K, Messinger, S, Sparrow-Bodenmiller, J, Wick, A, Delamater, A, Howorka, K, Meneghini, L. Mastering Your Diabetes: A Controlled Study of the Effect of Intensive Insulin Management Group Education on Patient Outcomes and Perceptions. American Diabetes Association, American Diabetes Association 70th Scientific Sessions Abstract Book, June, 2010 supplement to Diabetes.

Lauriola, V, Baidal, D, Froud, T, Messinger, S, Mineo, D, Bernetti, K, Herrada, E, Lagari, V, Ricordi, C, Alejandro, R. Effects of Exercise on Glucose Homeostasis in Clinical Islet Transplantation. International Pancreas and Islet Transplant Association, October, 2009

Alejandro, R., Lagari, V, Baidal, D, Messinger, S, Ricordi, C, Mendez, A Glucagon Response to Hyperglycemia Following Islet Cell Transplantation in Type 1 Diabetes Melliitus. International Pancreas and Islet Transplant Association, Vencie, October, 2009,

Lauriola, V, Baidal, D, Froud, T, Messinger, S, Mineo, D, Bernetti, K, Herrada, E, Lagari, V, Ricordi, C, Alejandro, R. Effects of Exercise on Glucose Homeostasis in Clinical Islet Transplantation. American Transplant Congress, May, 2009

Mita, A, Ricordi, C, Messinger, S, Miki, A, Misawa, R, Barker S, Molano, R.D., Haertter, R, Alvarez, A, Khan, A, Pileggi, A, Miyagawa, S, Inverardi, L, Ichii, H., Superiority of Iodixanol (Optiprep) over Ficoll in Human Islet Purification. American Transplant Congress, May, 2009.

Leitao C, Cure P, Messinger S, Pileggi A, Lenz O, Froud T, Faradji R, Selvaggi G, Ricordi C, Alejandro R. Kidney Function after Clinical Islet Transplantation. Presented at XXII International Congress of The Transplantation Society (Mini-Oral), August 2008.

Froud T, Faradji RN, Tharavanij T, Messinger S, Pileggi A, Baidal DA, Dinkins L, Selvaggi G, Ricordi C, Alejandro R. Long Term Insulin Independence and Restoration of First Phase Insulin Release after Supplemental Islet Infusion under Exenatide Treatment in Subjects with Islet Graft Dysfunction. Presented at XXII International Congress of The Transplantation Society (Oral), August 2008.

Tharavanij T, Betancourt A, Messinger S, Cure P, Leitao CB, Froud T, Ricordi C, Alejandro R. Improved Long Term Health Related Quality of Life after Islet Transplantation: A 6-year Follow-Up Study. Presented at XXII International Congress of The Transplantation Society (Poster), August 2008.

Froud T, Faradji RN, Messinger S, Cure P, Pileggi A, Mineo M, Tharavanij T, Mendez A, Ricordi C, Alejandro R. Long Term Metabolic and Hormonal Effects of Exenatide on Islet Transplant Recipients with Allograft Dysfunction. Presented at XXII International Congress of The Transplantation Society (Poster), August 2008.

Cristiane B. Leitão, Pablo Cure, Shari Messinger, Antonello Pileggi, Oliver Lenz, Tatiana Froud, Raquel N. Faradji, Gennaro Selvaggi, Warren Kupin, Thipaporn Tharavanij, David A. Baidal, Davide Mineo, Karina Bernetti, Eva Herrada, Camillo Ricordi, Rodolfo Alejandro. Kidney Function after Clinical Islet Transplantation. Presented at the American Diabetes Association 68th Scientific Sessions, (Poster), June 2008.

Thipaporn Tharavanij, Arthur Betancourt, Shari Messinger, Pablo Cure, David A. Baidal, Cristiane B. Leitao, Karina Bernetti, Tatiana Froud, Camillo Ricordi, Rodolfo Alejandro. Improved Long-term Quality of Life after Islet Transplantation. Presented at the American Diabetes Association 68th Scientific Sessions, (Oral Presentation), June 2008.

Cristiane B. Leitão, Pablo Cure, Shari Messinger, Antonello Pileggi, Oliver Lenz, Tatiana Froud, Raquel N. Faradji, Gennaro Selvaggi, Warren Kupin, Thipaporn Tharavanij, David A. Baidal, Davide Mineo, Karina Bernetti, Eva Herrada, Camillo Ricordi, Rodolfo Alejandro. Unchanged Renal Function after Clinical Islet Transplantation. Presented at the American Association of Clinical Endocrinologist meeting (Poster), May 2008.

Raquel N. Faradji, Thipaporn Tharavanij, Tatiana Froud, Shari Messinger, Antonello Pileggi, David A. Baidal, Davide Mineo, Cristiane Leitao, Pablo Cure, Aleida Saenz, Andrea Curry, Lourdes Dinkins, Gennaro Selvaggi, Camillo Ricordi and Rodolfo Alejandro. Long Term Insulin Independence and Restoration of First Phase Insulin Release after Supplemental Islet Infusion under Exenatide Treatment in Subjects with Islet Graft Dysfunction. Presented at the American Transplant Congress meeting (Oral Presentation), May 2008

Gorn, L., Faradji, R. N., Messinger, S., Monroy, K., Baidal, D., Froud, T., Mastrototaro, J., Ricordi, C., Alejandro, R.; Impact of Islet Transplantation on Glycemic Control as Evidenced by CGMS. American Association of Clinical Endocrinologists. May 2008, Orlando, Fl.

Monroy, K., Faradji, R. N., Allende, G., Gorn, L., Denham, M., Kury-Perez, E. M., Messinger, S., Cure, P., Baidal, D. A., Froud, T., Ponte, G., Ricordi, C., Pugliese, A., Alejandro, R.; Prevalence and Levels of GAD and IA-2 Autoantibodies in Patients with Long Duration of Type 1 Diabetes at the Time of Screening for Islet Transplantation. American Diabetes Association 67th Scientific Sessions, June 2007. [1036-P].
Diamantopoulos, S., Allende, G., Martin-Pagola, A., Ciancio, G., Ricordi, C., Messinger, S., Burke, G.W., Pugliese, A.; Recurrence of Type 1 Diabetes (T1DR) After Simultaneous Pancreas-Kidney (SPK) Transplantation is Associated With Islet Cell Autoantibody Conversion. Immunology of Diabetes Society. November 2007, Miami, Fl.

Toshiyuki, Y., Camillo, R., Messinger, S., Sakuma, Y., Miki, A., Rodriguez, R., Haertter, R., Khan, A., Alejandro, R., Ichii, H.; Deterioration and Variability of Highly Purified Collagenase Blends used in Clinical Islet Isolation. Congress of the International Pancreas and Islet Transplant Association. 2007.

Monroy, K., Faradji, R. N., Allende, G., Gorn, L., Denham, M., Kury-Perez, E. M., Messinger, S., Cure, P., Baidal, D., Froud, T., Ponte, G., Ricordi, C., Pugliese, A., Alejandro, R.; Prevalence and Levels of GAD and IA-2 Autoantibodies in Patients with Long Duration of Type 1 Diabetes at the Time of Screening for Islet Transplantation . American Diabetes Association’s 67th Scientific Sessions, (Poster). June 22-26, 2007, Chicago, IL.

Faradji, R. N., Froud, T., Monroy, K., Messinger, S., Pileggi, A., Baidal, D., Cure, P., Ponte, G., Selvaggi, G., Kenyon, N., Ricordi, C., Alejandro, R.; Metabolic Effects of Exenatide in Islet Transplant Recipients with Graft Dysfunction. World Transplant Congress. 2006, Boston, MA.

Monroy, K., Faradji, R. N., Pisani, L., Messinger, S., Gorn, L., Baidal, D. A., Ponte, G., Cure, P., Froud, T., Allende, G., Ricordi, C., Pugliese, A., Alejandro, R.; Prevalence of auto-antibodies in subject with type 1 diabetes at screening for islet cell transplantation. Diabetes 55 (Supplement 1: A222, 2006

Faradji, R., Monroy, K., Messinger, S., Pileggi, A., Froud, T., Baidal, D., Ricordi, C., Luzi, L., Alejandro R.; C-Peptide Glucose Ratio: A Better Indicator of Islet Graft Mass and Function than C-Peptide Alone in Islet Cell Transplantation. American Diabetes Association 66th Scientific Sessions, (Poster). 2006, Washington, DC.

Monroy, K., Faradji, R., Pisani, L., Messinger, S., Gorn, L., Baidal, D., Ponte, G., Cure, P., Froud, T., Allende, G., Ricordi, C., Pugliese, A., Alejandro, R.; Prevalence of Auto-Antibodies in Subjects with Type 1 Diabetes at Screening for Islet Cell Transplantation. American Diabetes Association 66th Scientific Sessions (Poster). 2006, Washington, DC.

Metsch, L. R., Pereyra, M. R., Messinger, S., del Rio, C., Anderson-Mahoney, P., Rudy, E., Loughlin, A., Strathdee, S., Gardner, L.; Continuing Risk Behaviors Among HIV-Positive Persons Not in HIV Care: A Longitudinal Examination from The ARTAS Study. National HIV Prevention Conference. 2006, Atlanta, GA.

Ponte, G., Alejandro, A., Pileggi, A., Minuzzi, A., Messinger, S., Cardenas, G., Kahn, A., Ichii, H., Ricordi, C., Goss, J., Alejandro, R.; Toward Maximizing the Success Rates of Human Islet Isolation: University of Miami and Baylor College of Medicine Experience. Congress of the International Pancreas and Islet Transplant Association. 2005, Geneva, Switzerland

Faradji, R. N., Monroy, K.., Froud, T., Baidal, D. A., Pileggi, A., Cure, P., Messinger, S., Luzi, L., Ricordi, C., Alejandro, R.; A simple measure to assess islet engraftment and function in islet allograft recipients. Congress of the International Pancreas and Islet Transplant Association. 2005, Geneva, Switzerland.

Faradji, R. N., Cure, P., Monroy, K., Froud, T., Baidal, D., Messinger, S., Ricordi, C., Alejandro, R.; C-peptide and glucose values in the peritransplant period after intraportal islet infusions in type 1 diabetes. Congress of the International Pancreas and Islet Transplant Association (Poster). 2005, Geneva, Switzerland.

Poggioli, R., Ponte, G., Baidal, D. A., Cure, P., Pileggi, A., Messinger, S., Betancourt, A., Froud ,T., Faradji, R. N., Ricordi, C., Alejandro, R.; Quality of Life after Islet Transplantation. Congress of the International Pancreas and Islet Transplant Association. 2005, Geneva, Switzerland.

Poggioli, R., Ponte, G., Baidal, D., Cure, P., Pileggi, A., Messinger S., Betancourt, A., Froud, T., Faradji, R. N., Ricordi, C., Alejandro, R.; Quality of Life after Islet Transplantation. American Diabetes Association. 2005, San Diego, CA.

Hafiz, M., Baidal, D., Poggioli, R., Froud, T., Ferreira, J., Rothenberg, L., Periz, M., Messinger, S., Ricordi, C., Alejandro, R., CMV, EBV, and Parvovirus Status in Patients with Type 1 DM Awaiting Islet Cell Transplantation. American Transplantation Congress. 2004, Boston, MA.

Perrino, T., Messinger, S., Fernández, M. I.; When Male Condoms are Not an Option: Initial Acceptability of Female Condoms Among Women at High Risk for HIV. American Public Health Association. 2004, Washington, DC.

Messinger, S., Duncan, R., Crandall, L., Cardenas, G., McCoy, C., Chitwood, D., Fernandez, M. I., Page, J. B., Messiah, S.; Creation of a Biostatistics Resource Center as a Shared Resource. American Public Health Association. 2004, Washington, DC.

Hafiz, M., Baidal, D., Poggioli, R., Froud, T., Ferreira, J., Messinger, S., Ricordi, C., Alejandro R.: CMV, EBV and Parvovirus Status in Patients with Type 1 Diabetes Mellitus Awaiting Islet Cell Transplantation. The XX International Congress of the Transplantation Society. 2004, Vienna, Austria.

Fernandez, M.I. Perrino, T., Messinger, S., Mattson, T., Collazo, J.; Dual Methods: Which Urban, Minority Women are Willing to Accept a Low Efficacious Microbicide. Workshop on Dual Protection: Preventing Disease and Protecting Fertility National Institute of Child Health & Human Development. National Institutes of Health. 2003, Bethesda, MD.

Messinger, S., Murray, S.; Nonparametric Paired Two-Sample Tests for Censored Survival Data Incorporating Longitudinal Covariate Information. Contributed Paper, ENAR Spring Meetings. 2003, Tampa, FL.

Messinger, S., Murray, S.; Nonparametric Paired Two-Sample Tests with Censored Mixture Distributions. Contributed Paper, ENAR Spring Meetings. 2001, Charlotte, NC.

Zhou, H. Messinger, S., Brown, M; A Model of Diabetes Progression II. American Statistical Association Joint Statistical Meetings. 2001, Atlanta, GA.

Zhou, H., Messinger, S., Brown, M.; A Model of Diabetes Progression II. Proceedings from the ASA Joint Statistical Meetings. 2001, Atlanta, GA.

Messinger, S., Brown, M., Herman, W.; A Model of Diabetes Progression, American Statistical Association Joint Statistical Meetings (Poster).1999, Baltimore, MD.

Messinger, S., Brown, M., Herman, W.; A Model of Diabetes Progression. Proceedings from the Joint Statistical Meetings. 1999, Baltimore, MD.